Enantyum Information
Dexketoprofen Trometamol
Enantyum
How does it work?
Dexketoprofen belongs to a class of medicines
called non-steroidal anti-inflammatory drugs (NSAIDs).
It works by blocking the action of a substance in the body called
cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals
in the body called prostaglandins. Prostaglandins are produced in response
to injury or certain diseases and would otherwise go on to cause swelling,
inflammation and pain.
By blocking cyclo-oxygenase, dexketoprofen prevents the production of
prostaglandins and therefore reduces inflammation and pain.
What is it used for?
• Mild to moderate pain
Warning!
• This medicine may cause dizziness and so may affect your ability to drive
or operate machinery safely. Do not drive or operate machinery until you
know how this medicine affects you and you are sure it won't affect your
performance.
• For fast relief of pain, take at least 30 minutes before food, as food
delays the absorption of this medicine from the gut.
• This medicine is not for long term use
Use with caution in
• Decreased heart function
• Disorders involving the formation of blood cells (haematopoietic
disorders)
• Elderly people
• Excess retention of water in the body tissues (fluid retention)
• History of allergies
• Long-term inflammation of skin and some internal organs (systemic lupus
erythematosus)
• Low volume of circulating blood (hypovolaemia)
• Mild to moderately decreased liver function
• Mildly decreased kidney function
• Syndrome with symptoms of systemic lupus erythematosus, scleroderma,
polymyositis, and raynaud's phenomenon (mixed connective tissue disease)
Not to be used in
• Active bleeding
• Allergy to aspirin or other medicines in this class (NSAIDs)
• Asthma or history of asthma
• Bleeding disorders
• Bleeding from the stomach or intestines
• Breastfeeding
• Children
• Crohn's disease
• History of stomach or duodenal ulcers or indigestion
• Inflammation of the bowel and back passage (ulcerative colitis)
• Inherited tendency to bleed (haemorrhagic diathesis)
• Moderate to severely decreased kidney function
• Peptic ulcers
• Pregnancy
• Severe heart failure
• Severely decreased liver function
This medicine should not be used if you are
allergic to one or any of its ingredients. Please inform your doctor or
pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this
medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding.
However, other medicines may be safely used in pregnancy or breastfeeding
providing the benefits to the mother outweigh the risks to the unborn baby.
Always inform your doctor if you are pregnant or planning a pregnancy,
before using any medicine.
• The manufacturer states not to use this medicine during pregnancy and
breastfeeding as there is insufficient safety information available. Seek
medical advice from your doctor.
Label warnings
• Take this medication half to one hour before food.
Side effects
Medicines and their possible side effects can affect individual people in
different ways. The following are some of the side effects that are known to
be associated with this medicine. Because a side effect is stated here, it
does not mean that all people using this medicine will experience that or
any side effect.
• Headache
• Swelling of the legs and ankles due to excess fluid retention (peripheral
oedema)
• Blood disorders
• Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting
or abdominal pain
• Indigestion (dyspepsia)
• Ulceration of the stomach or intestine
• Awareness of your heartbeat (palpitations)
• Dizziness
• Damage to the kidneys
• An extreme allergic reaction (anaphylaxis)
• Nervousness
• High blood pressure (hypertension)
• Narrowing of the airways (bronchospasm)
• Damage to the liver
The side effects listed above may not include
all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this
medicine, please read the information provided with the medicine or consult
your doctor or pharmacist.
How can this medicine affect other
medicines?
Dexketoprofen may decrease the removal of lithium and methotrexate from the
body, resulting in an increased risk of side-effects.
Dexketoprofen should not be taken with blood thinning or anti-clotting
medicines such as warfarin, as this may increase the risk of bleeding.
Dexketoprofen may enhance the effect of some antidiabetic medicines, which
could lead to low blood sugar levels.
Dexketoprofen may decrease the effects of blood pressure lowering medicines
such as diuretics and beta-blockers.
When taken with cyclosporin or tacrolimus, diuretics such as frusemide or
ACE inhibitors such as enalapril, there may be an increased risk of kidney
damage. Kidney function should be monitored in these cases.
When taken with any other NSAIDs there may be an increased risk of side
effects.
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